Fullmetal Alchemist: Brotherhood / Hagane No Renkinjutsushi

Synopsis

In this world, there exist people
with special abilities to manipulate objects and transform one object
into another. These people are known as alchemists. This process does
come with a cost though, the basic law of alchemy states that in order
to gain something you have to sacrifice something of the same value.

The main character is the famous alchemist Edward Elric - also known as
the Fullmetal Alchemist - who almost lost his little brother, Alphonse,
in an accident. Edward managed to contain his brother's soul in a large
suit of armor. While he did manage to save his brother's life, he had
to pay a great price himself.

To get back what they've lost, the brothers embark on a journey to find
the Philosophers Stone that is said to amplify the powers of an
alchemist enormously.

Fullmetal Alchemist: Brotherhood is a re-telling of the story from the manga point of view.